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*****JOURNAL OF PHARMACY AND PHARMACOLOGY*****
HARAGUCHI H  SAITO T  ISHIKAWA H  SANCHEZ Y  OGURA T  KUBO I  
INHIBITION OF LIPID PEROXIDATION BY SESQUITERPENOID IN HETEROTHECA INULOIDES.
In: J Pharm Pharmacol (1996 Apr) 48(4):441-3
ISSN: 0022-3573

A sesquiterpenoid, 7-hydroxy-3,4-dihydrocadalin, isolated from a Mexican
medicinal plant Heterotheca inuloides was evaluated as an antioxidant. This
sesquiterpenoid inhibited mitochondrial and microsomal lipid peroxidation
induced by Fe(III)-ADP/NADH or Fe(III)- ADP/NADPH. Furthermore,
7-hydroxy-3,4-dihydrocadalin protected red cells against oxidative haemolysis.
This sesquiterpene was thus shown to be effective in protecting biological
systems against oxidative stresses.

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*****PLANTA MEDICA*****
KUBO I  CHAUDHURI SK  KUBO Y  SANCHEZ Y  OGURA T  SAITO T  ISHIKAWA H  
HARAGUCHI H  
CYTOTOXIC AND ANTIOXIDATIVE SESQUITERPENOIDS FROM HETEROTHECA INULOIDES.
In: Planta Med (1996 Oct) 62(5):427-30
ISSN: 0032-0943

Four sesquiterpenoids, beta-caryophyllene, beta-caryophyllene 4,5 alpha-oxide,
7-hydroxy-3,4-dihydrocadalin, and 7-hydroxycadalin, isolated from the dried
flower of Heterotheca inuloides Cass. (Asteraceae), have been found to exhibit
cytotoxic activity against several solid tumor cell lines. Among them,
7-hydroxy-3,4- dihydrocadalin and 7-hydroxycadalin have also been found to
inhibit autoxidative and microsomal lipid peroxidation.

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