€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY***** de Vries JX Tauscher B Wurzel G Constituents of Justicia pectoralis Jacq. 2. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. In: Biomed Environ Mass Spectrom (1988 Apr 15) 15(8):413-7 ISSN: 0887-6134 The analysis of extracts from the South American plant Justicia pectoralis Jacq. permitted the identification, among other compounds, of coumarin, dihydrocoumarin, umbelliferone and 3-(2- hydroxyphenyl)propionic acid by gas chromatography/mass spectrometry (GC/MS); the acids and phenolic compounds were derivatized with diazomethane. GC/MS of simple coumarins, phenylpropionic acids and their hydroxylated isomers was performed after derivatization through methylation and trimethylsilylation; these results may be useful for the identification and quantification of these compounds in other biological materials. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****CHEMICAL AND PHARMACEUTICAL BULLETIN***** Okigawa M Maeda T Kawano N The isolation of neojusticin from Justicia procumbens LINN. In: Chem Pharm Bull (Tokyo) (1970 Apr) 18(4):862-3 ISSN: 0009-2363 [No Abstract Available] €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF ETHNOPHARMACOLOGY***** MacRae WD Towers GH Justicia pectoralis: a study of the basis for its use as a hallucinogenic snuff ingredient. In: J Ethnopharmacol (1984 Oct) 12(1):93-111 ISSN: 0378-8741 The use of Justicia pectoralis var. stenophylla as a Virola snuff admixture and also as the sole ingredient of a snuff was investigated. Extracts of the plant did not contain alkaloids, although the ubiquitous compound, betaine, was isolated because of its reaction with alkaloid reagents. Nor did extracts have any significant effect upon the gross behavioral effects, or increased spontaneous motor activity, elicited in mice by 5-methoxy-N,N- dimethyl-tryptamine (5-MeODMT), the primary psychotropic constituent of the Virola resin snuff. Coumarin and umbelliferone were identified because they are major constituents of the plant and because of their ability to relax smooth muscle. Registry Numbers: 107-43-7 (Betaine) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF NATURAL PRODUCTS***** Subbaraju GV Kumar KK Raju BL Pillai KR Reddy MC Justiciresinol, a new furanoid lignan from Justicia glauca. In: J Nat Prod (1991 Nov-Dec) 54(6):1639-41 ISSN: 0163-3864 [No Abstract Available] Registry Numbers: 136051-41-7 (justiciresinol) 9005-53-2 (Lignin) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Chen CC Hsin WC Ko FN Huang YL Ou JC Teng CM Antiplatelet arylnaphthalide lignans from Justicia procumbens. In: J Nat Prod (1996 Dec) 59(12):1149-50 ISSN: 0163-3864 Fractionation of the EtOH extract of Justicia procumbens, guided by antiplatelet bioassay, led to the isolation of nine known arylnaphthalide lignans, neojusticin A (1), justicidin B (2), justicidin A (3), taiwanin E methyl ether (4), neojusticin B (5), chinensinaphthol methyl ether (6), taiwanin E (8), chinensinaphthol (9), and diphyllin (10), and a new arylnaphthalide lignan that was characterized by spectral means as 4'-demethylchinensinaphthol methyl ether (7). Compounds 1, 2, 4, and 8 significantly inhibited platelet aggregation. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Joseph H Gleye J Moulis C Mensah LJ Roussakis C Gratas C Justicidin B, a cytotoxic principle from Justicia pectoralis. In: J Nat Prod (1988 May-Jun) 51(3):599-600 ISSN: 0163-3864 [No Abstract Available] Registry Numbers: 1936-18-1 (salutaridine) 25001-57-4 (justicidin A) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Fukamiya N Lee KH Antitumor agents, 81. Justicidin-A and diphyllin, two cytotoxic principles from Justicia procumbens. In: J Nat Prod (1986 Mar-Apr) 49(2):348-50 ISSN: 0163-3864 [No Abstract Available] Registry Numbers: 22055-22-7 (diphyllin) 25001-57-4 (justicidin A) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PHYTOCHEMISTRY***** Asano J Chiba K Tada M Yoshii T Antiviral activity of lignans and their glycosides from Justicia procumbens. In: Phytochemistry (1996 Jun) 42(3):713-7 ISSN: 0031-9422 Ten antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O- glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O- glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml- 1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33). Registry Numbers: 22055-22-7 (diphyllin) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****REVISTA DE INVESTIGACION CLINICA***** Ponce-Macotela M Navarro-Alegria I Martinez-Gordillo MN Alvarez-Chacon R [In vitro effect against Giardia of 14 plant extracts] Efecto antigiardiasico in vitro de 14 extractos de plantas. In: Rev Invest Clin (1994 Sep-Oct) 46(5):343-7 ISSN: 0034-8376 (Published in Spanish) OBJECTIVE. To investigate antigiardiasic activity in plants used in Mexico as antidiarrheics and/or antiparasitics. MATERIALS AND METHODS. Fourteen species were evaluated. The antigiardiasic activity was measured in vitro in a blinded fashion using trophozoites of Giardia duodenalis incubated with plant extracts. The viability of trophozoites was ascertained using MTT (3-[4,5-dimethylthiazol-2-il]- 2, 5-diphenyl tetrazolium bromide) which is reduced to MTT-formazan by the activity of live trophozoites. The reduced MTT was extracted with an acidified alcohol (2-propanol with HCI 0.04 M) and measured in a spectrophotometer at 570 nm. Negative (trophozoites without extract) and positive controls (incubated with tinadazol) were included. RESULTS. The scientific and trivial names of the plants are given (trivials in Spanish marked by an asterisk). They had the following trophozoite mortality (mean +/- SD in percent): Justicia spicigera (muicle*) = 91 +/- 0.5; Lipia beriandieri (oregano) = 90 +/- 0.6; Psidium guajava (guava) = 87 +/- 1.0; positive control of tinidazol = 79 +/- 1.9; Punica granutus (granado*) = 78 +/- 1.3; Magnifera indica (mango) = 77 +/- 1.0; Plantago major (lante*) = 76 +/- 1.2; Cupressus semperbirens (cipres) = 73 +/- 1.2; Castella tormentosa (chaparro amargoso*) = 70 +/- 0.7; Hematoxilon campechanum (palo de Campeche*) = 67 +/- 1.2. Without or with a low mean activity were Prosopis juliflora (mesquite*) and Rizophora mangle (mangle*) with 0%, Oriza sativa (rice) with 5%, Capsicum annum (pimiento*) with 21% and Persea americana (avocado) with 23%. There were no associations of the antigiardiasic effect with concentration or osmolality of the extracts. CONCLUSIONS. A clear in vitro antigiardiasic effects was seen in nine species. Three of them were superior to tinidazol which is a drug of common use in the treatment of giardiasis. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€