€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****BIOORGANIC AND MEDICINAL CHEMISTRY***** LEE TT KASHIWADA Y HUANG L SNIDER J COSENTINO M LEE KH SUKSDORFIN: AN ANTI-HIV PRINCIPLE FROM LOMATIUM SUKSDORFII, ITS STRUCTURE-ACTIVITY CORRELATION WITH RELATED COUMARINS, AND SYNERGISTIC EFFECTS WITH ANTI-AIDS NUCLEOSIDES. In: Bioorg Med Chem (1994 Oct) 2(10):1051-6 ISSN: 0968-0896 Suksdorfin (1), which is isolated from the fruit of Lomatium suksdorfii, was found to be able to inhibit HIV-1 replication in the T cell line, H9, with an average EC50 value of 2.6 +/- 2.1 microM. In addition, suksdorfin was also suppressive during acute HIV-1 infections of peripheral blood mononuclear cells, monocyte/macrophages and the promonocytic cell line, U937. Combinations of 1 and the anti-HIV nucleosides ddI and ddC demonstrated statistical synergy in inhibiting HIV-1 replication (ddC > ddI). However, the viral inhibition mediated by combining 1 with AZT was not statistically synergistic. Furthermore, the presence of suksdorfin did not antagonize the suppression mediated by the three nucleoside reverse transcriptase inhibitors. Comparison of the structure and activity of 1 with those of ten related compounds indicated that the dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity. Registry Numbers: 53023-17-9 (suksdorfin) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF ETHNOPHARMACOLOGY***** MCCUTCHEON AR ROBERTS TE GIBBONS E ELLIS SM BABIUK LA HANCOCK RE TOWERS GH ANTIVIRAL SCREENING OF BRITISH COLUMBIAN MEDICINAL PLANTS. In: J Ethnopharmacol (1995 Dec 1) 49(2):101-10 ISSN: 0378-8741 One hundred methanolic plant extracts were screened for antiviral activity against seven viruses. Twelve extracts were found to have antiviral activity at the non-cytotoxic concentrations tested. The extracts of Rosa nutkana and Amelanchier alnifolia, both members of the Rosaceae, were very active against an enteric coronavirus. A root extract of another member of the Rosaceae, Potentilla arguta, completely inhibited respiratory syncytial virus. A Sambucus racemosa branch tip extract was also very active against respiratory syncytial virus while the inner bark extract of Oplopanax horridus partially inhibited this virus. An extract of Ipomopsis aggregata demonstrated very good activity against parainfluenza virus type 3. A Lomatium dissectum root extract completely inhibited the cytopathic effects of rotavirus. In addition to these, extracts prepared from the following plants exhibited antiviral activity against herpesvirus type 1: Cardamine angulata, Conocephalum conicum, Lysichiton americanum, Polypodium glycyrrhiza and Verbascum thapsus. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF NATURAL PRODUCTS***** VANWAGENEN BC HUDDLESTON J CARDELLINA JH 2D NATIVE AMERICAN FOOD AND MEDICINAL PLANTS, 8. WATER-SOLUBLE CONSTITUENTS OF LOMATIUM DISSECTUM. In: J Nat Prod (1988 Jan-Feb) 51(1):136-41 ISSN: 0163-3864 A continuing investigation of the umbellifer Lomatium dissectum has resulted in the isolation of a known flavonoid [1] and three coumarin glycosides [2-4], two of which are previously unreported. One of these new compounds [4] contains apiose, a sugar uncommon in the coumarins. The ichthyotoxicity of the plant extracts has been traced to the tetronic acids isolated earlier in this study. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€