€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****BIOCHEMICAL PHARMACOLOGY***** Wang P Kang J Zheng R Yang Z Lu J Gao J Jia Z Scavenging effects of phenylpropanoid glycosides from Pedicularis on superoxide anion and hydroxyl radical by the spin trapping method(95)02255-4. In: Biochem Pharmacol (1996 Mar 8) 51(5):687-91 ISSN: 0006-2952 The scavenging activities of six phenylpropanoid glycosides, i.e. leucosceptoside A and martynoside, isolated from Pedicularis alashanica Maxim, verbascoside, and pediculariosides A, M and N isolated from Pedicularis striata Pall ssp. arachnoidea Franch Tsoong, on superoxide anion and hydroxyl radicals have been studied by the spin trapping method. The results demonstrated that the number of phenolic hydroxyl groups in the structures of the phenylpropanoid glycosides is related to their scavenging activities. The scavenging effects of the phenylpropanoid glycosides possessing two o-dihydroxyl groups were stronger than the effects of the compounds possessing two o-hydroxy-methoxy groups. Registry Numbers: 11062-77-4 (Superoxides) 3317-61-1 (5,5-dimethyl-1-pyrroline-1-oxide) 3352-57-6 (Hydroxyl Radical) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****CHEMISTRY AND PHYSICS OF LIPIDS***** Zheng RL Wang PF Li J Liu ZM Jia ZJ Inhibition of the autoxidation of linoleic acid by phenylpropanoid glycosides from Pedicularis in micelles. In: Chem Phys Lipids (1993 Jun) 65(2):151-4 ISSN: 0009-3084 The activities of six phenylpropanoid glycosides as chain-breaking antioxidants have been studied for the autoxidation of linoleic acid in cetyl trimethylammonium bromide (CTAB) micelles at 37 degrees C. Verbascoside, isoverbascoside, echinacoside and pedicularioside A, which possess four phenolic hydroxyl groups, exhibited antioxidant activities, while cistanoside D possessing only two phenolic hydroxyl groups and permethyl verbascoside without phenolic hydroxyl group did not suppress the oxidation appreciably. The ratio of rate constants for inhibition and propagation kinh/kp and stoichiometric factor n were determined. Registry Numbers: 13217-66-8 (2,2'-azobis(2-amidinopropane)) 135010-61-6 (pedicularioside A) 2197-37-7 (linoleic acid) 61276-17-3 (verbascoside) 6899-10-1 (cetrimonium) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ **CHUNG-KUO CHUNG YAO TSA CHIH CHINA JOURNAL OF CHINESE MATERIA MEDICA* Shen L Yang L [Identification of Yi nationality's secret recipe for treating snakebite] In: Chung Kuo Chung Yao Tsa Chih (1991 Jun) 16(6):328-9, 381 ISSN: 1001-5302 (Published in Chinese) The authors have investigated and found an effective secret recipe for the treatment of snakebite in Mabian, an autonomous county of the Yi nationality in Sichuan Province. Morphologic identification has shown that the recipe is composed of the herb of Pedicularis muscicola and the rhizome of Polygonum viviparum in the ratio of one to one. To facilitate further application, popularization and improvement of the recipe, its histological characteristics have also been studied microscopically. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Yang L [Chemical constituents of Pedicularis muscicola Maxim] In: Chung Kuo Chung Yao Tsa Chih (1992 Aug) 17(8):485-7, 512 ISSN: 1001-5302 (Published in Chinese) It is one of the main components in an effective secret recipe for the treatment of snakebite in Mabian, an autonomaus county of the Yi nationality in Sichuan province. Four compounds have been isolated from the herb of Pedicularis muscicola. On the basis of spectrometric analysis and physico-chemical constants, they were identified as pediculariside, D-mannitol, arachidic acid and hentriacontane. Registry Numbers: 69-65-8 (Mannitol) 81203-55-6 (pedicularioside) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****CHUNG-KUO YAO LI HSUEH PAO [ACTA PHARMACOLOGICA SINICA]***** Li J Zheng RL Liu ZM Jia ZJ Scavenging effects of phenylpropanoid glycosides on superoxide and its antioxidation effect. In: Chung Kuo Yao Li Hsueh Pao (1992 Sep) 13(5):427-30 ISSN: 0253-9756 The antioxidative activities of six phenylpropaniod glycosides (PPG) extracted from Pedicularis striata and Pedicularis lasiophrys for inhibiting the lipid peroxidation induced by Fe2+/ascorbic acid in mouse liver microsome may be related to the number and steric position of phenolic hydroxyl groups (PHG) they possess (32.5 mumol.L- 1 to 65.0 mumol.L-1). The scavenging effects of PPG for superoxide produced by NBT/PMS/NADH system may be related to both the number of PHG and their conjugated system (16.0 mumol.L-1 to 65.0 mumol.L-1). Registry Numbers: 542-78-9 (Malondialdehyde) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****INTERNATIONAL JOURNAL OF RADIATION BIOLOGY***** Li W Zheng R Su B Jia Z Li H Jiang Y Yao S Lin N Repair of dGMP hydroxyl radical adducts by verbascoside via electron transfer: a pulse radiolysis study. In: Int J Radiat Biol (1996 Apr) 69(4):481-5 ISSN: 0955-3002 The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'- deoxyguanosine-5'-monophosphate (dGMP) and VER, it was found that the transient absorption spectrum of the hydroxyl adduct of dGMP decays with the formation of that of the phenoxyl radical of VER, several tens of microseconds after the electron pulse. From the formation kinetics of the phenoxyl radical of VER, the rate constant of the repair reaction was determined to be 1.12 x 10(9) dm(3) mol(-1) s(- 1). Registry Numbers: 3352-57-6 (Hydroxyl Radical) 61276-17-3 (verbascoside) 902-04-5 (2'-deoxyguanosine 5'-phosphate) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PHYTOCHEMISTRY***** Jia ZJ Liu ZM Wang CZ Phenylpropanoid and iridoid glycosides from Pedicularis lasiophrys. In: Phytochemistry (1992 Jan) 31(1):263-6 ISSN: 0031-9422 Two new compounds, pedicularioside E and F, were isolated from whole plants of Pedicularis lasiophrys, along with the four known compounds, verbascoside, cistanoside C, cistanoside D and 8- epiloganin. On the basis of spectral and chemical evidence, pedicularioside E and F were identified to be 1'-O-beta-D-(3-methoxy- 4-hydroxy-beta-phenyl)-ethyl-6'-O-feruloyl- alpha-L-(2-acetyl)- rhamnosyl-(1----3')-4'-acetylglucopyranoside and shanzhisin methyl ester cellobioside, respectively. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Jia ZJ Liu ZM Wang CZ Phenylpropanoid and iridoid glycosides from Pedicularis spicata. In: Phytochemistry (1991) 30(11):3745-7 ISSN: 0031-9422 One new phenylpropanoid glycoside, pedicularioside H, and five known glycosides, gardoside methyl ester, shanzhiside methyl ester, 5- deoxypulchelloside I, verbascoside and pedicularioside A, were isolated from whole plants of Pedicularis spicata. On the basis of the spectral data, chemical evidence and comparison with authentic samples, pedicularioside H was determined to be 1'-O-beta-D-(3- methoxy-4-hydroxy-beta-phenyl)-ethyl-4'-O-feruloyl- beta-D- apiosyl(1- ---3')-alpha-L-rhamnosyl-(1----6')-glucopyranoside . Registry Numbers: 138989-16-9 (pedicularioside H) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Liu ZM Jia ZJ Phenylpropanoid and iridoid glycosides from Pedicularis striata. In: Phytochemistry (1991) 30(4):1341-4 ISSN: 0031-9422 A new phenylpropanoid glycoside, pedicularioside A, and five known glycosides, acteoside, isoacteoside, decaffeoylacteoside, echinacoside and 8-acetylharpagide, were isolated from whole plants of Pedicularis striata. On the basis of spectral and chemical evidence, pedicularioside A was shown to be 1'-O-beta-D-(3,4- dihydroxy-beta-phenyl)-ethyl-4'-O-caffeoyl-beta-D -apiosyl-(1----3')- alpha-L-rhamnosyl-(1----6')-glucopyranosi de. Registry Numbers: 135010-61-6 (pedicularioside A) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PLANTA MEDICA***** Li J Wang PF Zheng R Liu ZM Jia Z Protection of phenylpropanoid glycosides from Pedicularis against oxidative hemolysis in vitro. In: Planta Med (1993 Aug) 59(4):315-7 ISSN: 0032-0943 Five phenylpropanoid glycosides from Pedicularis, isoacteoside (1), acteoside (2), echinacoside (3), pedicularioside A (4), cistanoside D (5), and a chemically synthesised compound, permethylacteoside (6), as phenolic compounds can protect against oxidative hemolysis. The inhibitory activity is related to the number of phenolic hydroxy groups. Compounds 1, 2, 3, and 4, possessing four phenolic hydroxy groups, have stronger inhibitory activities than 5 possessing only two phenolic hydroxy groups, and compound 6 with no phenolic hydroxy group inhibited oxidative hemolysis weakly. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****SCIENCE IN CHINA. SERIES C, LIFE SCIENCES***** Wang P Zheng R Gao J Jia Z Wang W Yao S Zhang J Lin N Reaction of hydroxyl radical with phenylpropanoid glycosides from Pedicularis species: a pulse radiolysis study. In: Sci China C Life Sci (1996 Apr) 39(2):154-8 ISSN: 1006-9305 Using pulse radiolysis technique, the reaction between hydroxyl radical and 7 phenylpropanoid glycosides: echinacoside, verbascoside, leucosceptoside A, martynoside, pediculariosides A, M and N which were isolated from Pedicularis were examined. The rate constants of these reactions were determined by transient absorption spectra. All 7 phenylpropanoid glycosides react with hydroxyl radical at high rate constants within (0.97-1.91) x 10(10)L.mol-1.s-1, suggesting that they are effective hydroxyl radical scavengers. The results demonstrate that the numbers of phenolic hydroxyl groups of phenylpropanoid glycosides are directly related to their scavenging activities. The scavenging activities are likely related to o- dihydroxy group of phenylpropanoid glycosides as well. Registry Numbers: 3352-57-6 (Hydroxyl Radical) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€