€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****ACTA POLONIAE PHARMACEUTICA***** Chodera A Dabrowska K Sloderbach A Skrzypczak L Budzianowski J [Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes] Wplyw frakcji flawonoidowych gatunkow rodzaju Solidago L. na diureze i ste~zenie elektrolitow. In: Acta Pol Pharm (1991) 48(5-6):35-7 ISSN: 0001-6837 (Published in Polish) The flavonoid fractions of Solidago virgaurea L.S. gigantea Ait., S. canadensis var. canadensis and S. canadensis var. "scabra" flowers were administrated p.o. to rats and showed diuretic activity. Increase in overnight diuresis reached 57-88%. Decrease of overnight excretion of potassium and sodium also occurred after administration of form examined fractions. The flavonoids from S. virgaurea and S. canadensis var. canadensis caused increased excretion of calcium with urine. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****ARZNEIMITTEL-FORSCHUNG***** von Kruedener S Schneider W Elstner EF Effects of extracts from Populus tremula L., solidago virgaurea L. and Fraxinus excelsior L. on various myeloperoxidase systems. In: Arzneimittelforschung (1996 Aug) 46(8):809-14 ISSN: 0004-4172 Extracts from Populus tremula, Solidago virgaurea and Fraxinus excelsior are used as anti-inflammatory drugs. The effects of these extracts on myeloperoxidase (MPO), an enzyme liberated by activated granulocytes and known to produce the destructive agent hypochloric acid, were investigated. Populus and Fraxinus inhibited this enzyme, Solidago was without effect. These results were obtained concordantly with four different MPO-assays (H2O2/MPO; X/XOD/MPO; activated PMN; and elastase/alpha 1-PI-MPO). Fractionation of Populus and Fraxinus extracts showed that this inhibition is due to several different compounds. Well known or wide spread substances as e.g. rutin, salicylic acid, chlorogenic acid etc. had no or only little effect on the enzyme. Registry Numbers: EC 1.1.3.22 (Xanthine Oxidase) EC 1.11.1.7 (Peroxidase) 22059-21-8 (1-aminocyclopropane-1-carboxylic acid) 7722-84-1 (Hydrogen Peroxide) 7790-92-3 (Hypochlorous Acid) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ el-Ghazaly M Khayyal MT Okpanyi SN Arens-Corell M Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior. In: Arzneimittelforschung (1992 Mar) 42(3):333-6 ISSN: 0004-4172 Aqueous/alcoholic extracts of Populus tremula, Solidago virgaurea and Fraxinus excelsior (components of Phytodolor N) were tested individually and in 3 different combinations for anti-inflammatory activity using carrageenan induced edema and/or adjuvant induced arthritis of the rat paw. The tested combinations as well as the individual extracts significantly reduced the paw edema to varying degrees and also dose dependently inhibited the arthritic paw volume. The anti-inflammatory activity of the combinations was respectively comparable to the tested doses of diclofenac. Registry Numbers: 15307-86-5 (Diclofenac) 9000-07-1 (Carrageenan) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Okpanyi SN Schirpke-von Paczensky R Dickson D [Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model] Antiphlogistische, analgetische und antipyretische Wirkung unterschiedlicher Pflanzenextrakte und deren Kombination im Tiermodell. In: Arzneimittelforschung (1989 Jun) 39(6):698-703 ISSN: 0004-4172 (Published in German) Antiinflammatory, Analgesic and Antipyretic Effects of Various Plant Extracts and a Combination Thereof in Animal Models. The three main components comprising the efficacy of non-steroidal antiinflammatory drugs could be demonstrated for STW 1 in different animal models. The phytotherapeutic preparation, containing three individual plant extracts (Populus tremula, Solidago virgaurea, Fraxinus excelsior) produced dose-dependent antiinflammatory, analgesic and antipyretic effects which were similar to those of the reference substances salicyl alcohol and indometacin. As each of the individual extracts displayed considerable efficacy, it may be assumed that each of them contributes to the overall effects of the combination STW 1. Registry Numbers: 363-03-1 (phenylbenzoquinone) 53-86-1 (Indomethacin) 9000-07-1 (Carrageenan) 9004-54-0 (Dextrans) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Meyer B Schneider W Elstner EF Antioxidative properties of alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea. In: Arzneimittelforschung (1995 Feb) 45(2):174-6 ISSN: 0004-4172 Aqueous-ethanolic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea inhibit biochemical model reactions representing inflammatory situations to various extents. These model reactions include xanthine oxidase, diaphorase in the presence of the autoxidizable quinone juglone, lipoxygenase and photodynamic reactions driven by riboflavin or rose bengal. The tested extracts are the components of the phytomedicine Phytodolor N (abbreviated as PD) which possesses antipyretic, analgesic, antiinflammatory and antirheumatic activity. Since several reactive oxygen species produced by the mentioned model systems are also involved in inflammatory processes, the beneficial activities of the complete drug may at least in part be due to the reported antioxidative functions of the individual components. Registry Numbers: EC 1.1.3.22 (Xanthine Oxidase) EC 1.6.99.1 (NADPH Dehydrogenase) 11062-77-4 (Superoxides) 141444-11-3 (Phytodolor N) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Strehl E Schneider W Elstner EF Inhibition of dihydrofolate reductase activity by alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea. In: Arzneimittelforschung (1995 Feb) 45(2):172-3 ISSN: 0004-4172 Aqueous-ethanolic extracts of Fraxinus excelsior, Populus, tremula and Solidago virgaurea in a combination of 1: 3: 1 (v/v/v) are the components of the plant drug Phytodolor N (abbreviated as PD), which exhibits antipyretic, analgesic and antirheumatic activity. Similar to a broad variety of synthetic non-steroidal anti-inflammatories the mentioned plant extracts inhibit dihydrofolate reductase. The following concentrations as percentage in the test volumes represent the individual I50-values: F. excelsior = 0.26% (v/v); P. tremula = 0.46% (v/v) and S. virgaurea = 0.6% (v/v). The combined extracts in PD exhibit an I50 at 0.3% (v/v). Testing the activity of the water- soluble compounds of corresponding dry extracts, the activity of F. excelsior with an apparent I50-value of 0.008% (w/v) by far dominates the inhibitory overall effect of the combination (I50 = 0.014%, w/v). Registry Numbers: EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase) 141444-11-3 (Phytodolor N) 64-17-5 (Alcohol, Ethyl) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ von Kruedener S Schneider W Elstner EF A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. In: Arzneimittelforschung (1995 Feb) 45(2):169-71 ISSN: 0004-4172 Anti-inflammatory properties of Populus tremula are mainly deduced from its components, the well investigated salicylates. Solidago extracts have spasmolytic, antihypertensive and diuretic effects. Fraxinus excelsior itself has hardly been investigated, but its coumarin components proved to have a variety of pharmacological properties, i.e. inhibition of T-cell activation and of the arachidonic acid cascade. Phytodolor N (abbreviated as PD) is a combination of the above mentioned plants. Various in vitro and especially in vivo studies proved its anti-inflammatory and antirheumatic properties, often comparable to non-steroidal anti- inflammatories, but with little or no side effects. Registry Numbers: 141444-11-3 (Phytodolor N) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Leuschner J Anti-inflammatory, spasmolytic and diuretic effects of a commercially available Solidago gigantea Herb. extract. In: Arzneimittelforschung (1995 Feb) 45(2):165-8 ISSN: 0004-4172 The evaluation of a commercially available Solidago gigantea Herb. extract (Urol mono) revealed pronounced anti-inflammatory properties in the rat with respect to a reduction of the carrageenin-induced rat paw oedema. A direct comparison with diclofenac-Na (3 mg/kg b.w. p.o.) revealed that a high dose of Solidago gigantea Herb. extract possesses the same anti-inflammatory efficacy as diclofenac-Na. In addition, the Solidago gigantea Herb. extract exhibited moderate spasmolytic and diuretic properties. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****CHEMICAL AND PHARMACEUTICAL BULLETIN***** Matsunaga H Katano M Tasaki M Yamamoto H Mori M Takata K Inhibitory effect of cis-dehydromatricaria ester isolated from Solidago altissima on the growth of mammalian cells. In: Chem Pharm Bull (Tokyo) (1990 Dec) 38(12):3483-4 ISSN: 0009-2363 A cell growth inhibitory substance was isolated from Solidago altissima, which is known as a naturalized weed. The data of infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectrum, and mass spectrum were identical with those of cis-dehydromatricaria ester. The compound inhibited both tumor and normal mammalian cells. Registry Numbers: 7329-73-9 (dehydromatricaria methyl ester) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Miyase T Inose Y Ueno A Studies on the constituents of Solidago virga-aurea L. III. Structures of solidagosaponins XXI-XXIX. In: Chem Pharm Bull (Tokyo) (1994 Mar) 42(3):617-24 ISSN: 0009-2363 From the most polar fractions of Solidago virga-aurea L. (Compositae), 9 oleanane-type triterpene saponins named solidagosaponins XXI-XXIX (1-9) were isolated, together with a known saponin, virgaureasaponin 2 (10). These saponins are bisdesmosidic glycosides having two monosaccharides at C-3 and four or five monosaccharides at C-28. Their structures were established on the basis of spectroscopic and chemical evidence. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF CHROMATOGRAPHY. B, BIOMEDICAL APPLICATIONS***** Bongartz D Hesse A Selective extraction of quercetrin in vegetable drugs and urine by off-line coupling of boronic acid affinity chromatography and high- performance liquid chromatography. In: J Chromatogr B Biomed Appl (1995 Nov 17) 673(2):223-30 ISSN: 0378-4347 Quercetrin, quercetin and chlorogenic acid were measured in urine or in drugs by combination of boronic acid affinity chromatography and HPLC. Simple reversed-phase HPLC with UV detection was used to determine quercetrin in five different Solidago virgaurea drugs. For determination of quercetrin in human urine immobilized boronic acid was applied for sample pretreatment. this procedure leads to a determination limit of 0.01 micrograms/ml with a recovery rate of 95.3%. The first results using this method for quercetrin pharmacokinetics are presented. Registry Numbers: 117-39-5 (Quercetin) 327-97-9 (Chlorogenic Acid) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PHARMAZIE***** Bader G Kulhanek Y Ziegler-Bohme H [The antifungal action of polygalacic acid glycosides] Zur antimyzetischen Wirksamkeit von Polygalasaureglycosiden. In: Pharmazie (1990 Jul) 45(8):618-20 ISSN: 0031-7144 (Published in German) Triterpenoid glycosides obtained from Solidago virgaurea L. and Bellis perennis L. (Asteraceae) inhibit the growth of human- pathogenic yeasts (Candida and Cryptococcus species). First results are given of the investigations on the mode of action and the relationships between structure and activity of these compounds. The intensity of growth inhibition is influenced particularly by the carbohydrate chains of the glycosides. Monodesmosidic as well as bisdesmosidic glycosides of polygalacic acid exert fungicidic effects. Registry Numbers: 22338-71-2 (polygalacic acid) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Metzner J Hirschelmann R Hiller K [Antiphlogistic and analgesic effects of leiocarposide, a phenolic bisglucoside of Solidago virgaurea L.] Antiphlogistische und analgetische Wirkungen von Leiocarposid, einem phenolischen Bisglucosid aus Solidago virgaurea L. In: Pharmazie (1984 Dec) 39(12):869-70 ISSN: 0031-7144 (Published in German) [No Abstract Available] Registry Numbers: 71953-77-0 (leiocarposide) 9000-07-1 (Carrageenan) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Fotsch G Pfeifer S Bartoszek M Franke P Hiller K [Biotransformation of phenolglycosides leiocarposide and salicin] Biotransformation der Phenolglycoside Leiocarposid und Salicin. In: Pharmazie (1989 Aug) 44(8):555-8 ISSN: 0031-7144 (Published in German) Leiocarposide (1; 3-beta-D-glucopyranosyloxy-2-methoxy-6-hydroxy- benzoic acid -2'-beta-D-glucopyranosyloxybenzyl ester) is a phenolic glycoside from Solidago virgaurea L. After oral administration to rats it will be only poorly absorbed and mostly unchanged fecaly excreted. In the urine were found less than 10% as metabolites: leiocarpic acid (3; 3,6-dihydroxy-2-methoxy-benzoic acid, 2% of the administered dose), 3-conjugates (2%), salicylic acid (5; 0.5%), 5- conjugates (0.1%) and salicyluric acid (6; 0.5%). On the other hand salicin (2), structural part of 1, is good absorbed. In the urine were excreted 15% of the unchanged drug and the following metabolites: 0.1% saligenin (4), 30% 5, 5% 5-conjugates, 0.1% 6, 2% gentisic acid (7) and 0.1% 2,3-dihydroxy-benzoic acid (8). The different metabolic rates are explicable by the high stability of the ester bond of 1. It is hydrolyzed in artificial intestinal fluid only very slowly (t1/2 = 41.7 h). Registry Numbers: 138-52-3 (salicin) 71953-77-0 (leiocarposide) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Murach M Hiller K Franke P Hintsche R [Bayogenin -- a sapogenin in Solidago canadensis L. 2. The saponins of the species Solidago] Bayogenin - ein Sapogenin in Solidago canadensis L. 2. Mitteilung: Zur Kenntnis der Saponine der Gattung Solidago In: Pharmazie (1975 Sep) 30(9):619-20 ISSN: 0031-7144 (Published in German) [No Abstract Available] €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Bader G Plohmann B Hiller K Franz G Cytotoxicity of triterpenoid saponins. Part 1: Activities against tumor cells in vitro and hemolytical index. In: Pharmazie (1996 Jun) 51(6):414-7 ISSN: 0031-7144 Genuine saponins from Solidago virgaurea L., Heteropappus altaicus (Willd.) Novopokr., H. biennis (Ldb.) Tamamsch., and Helianthus annuus L. (Asteraceae) as well as related carbohydrate modified glycosides of polygalacic acid and echinocystic acid were investigated in view of their structure related cytotoxicity in the YAC-1- and in the P-815-tumor cell model. The cytotoxic activities are influenced by both, the O-glycosylation pattern at carbon atom 3 and 28 of the sapogenin. The IC50-values of bisdesmosides of polygalacic acid are lower than those of the corresponding prosapogenins. The acylglycosidic carbohydrate sequence 1-fucose-2 <-- 1-rhamnose-4 <-- 1-xylose-3 <-- 1-rhamnose of these bisdesmosides showed the highest cytotoxic effect. One etherglycosidic linked glucose unit at C-3 of the aglycone is essential, a difference in activity to the disaccharide laminaribiose at the same position cannot be observed. In the case of echinocystic acid glycosides the acylglycosidic carbohydrate sequence 1-arabinose-2 <-- 1-rhamnose-4 <- - 1-glucose seems to influence the rate of the cytotoxic effects. By comparing the concentration of the saponins with the complete hemolysis time it is possible to determine the hemolytical index in a very short time. Cytotoxicity against tumor cells correlated with the basic structure of the saponins are in accordance with the hemolytical effect. Sugar moieties play an important role for the hemolytical index. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Bader G Binder K Hiller K Ziegler-Bohme H [The antifungal action of triterpene saponins of Solidago virgaurea L.] Zur antimycetischen Wirksamkeit von Triterpensaponinen aus Solidago virgaurea L. In: Pharmazie (1987 Feb) 42(2):140 ISSN: 0031-7144 (Published in German) [No Abstract Available] €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PHYTOCHEMISTRY***** Lu T Vargas D Franzblau SG Fischer NH Diterpenes from Solidago rugosa. In: Phytochemistry (1995 Jan) 38(2):451-6 ISSN: 0031-9422 Investigation of the roots and aerial parts of Solidago rugosa afforded the known diterpenes kolavenol, hardwickiic acid, (-)-kaur- 16-en-19-oic acid, (+)-manool, (+)-3 beta-hydroxymanool, manoyl oxide and ent-abietic acid. In addition, the new labdane diterpene (+)-18- tigloyloxymanool and four new ent-abietanes were obtained. The structures of all known and new compounds were elucidated by spectroscopic methods, especially high-field 1H and 13C NMR, and inverse 1H-13C-correlation techniques, as well as chemical transformations. Six diterpenes were tested against Mycobacterium tuberculosis and M. avium, but showed no significant activities with minimum inhibitory concentrations of > 100 micrograms ml-1. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Bader G Wray V Hiller K Virgaureasaponin 3, a 3,28-bisdesmosidic triterpenoid saponin from Solidago virgaurea. In: Phytochemistry (1992 Feb) 31(2):621-3 ISSN: 0031-9422 A new 3,28-bisdesmosidic triterpenoid glycoside was isolated from the mixture of deacylated saponins from the aerial parts of Solidago virgaurea. The structure of virgaureasaponin 3 was determined as 3-O- beta-D-glucopyranosyl-(1----3)-beta-D-glucopyranosylpolygalacic++ + acid 28-O-beta-D-fucopyranosyl-(1----2)-alpha-L-rhamnopyranosyl-(1---- 3)-beta -D- xylopyranosyl-(1----4)-alpha-L-rhamnopyranosyl-(1----2)- beta-D-fucopyran oside mainly by various 2D NMR techniques. Registry Numbers: 112509-54-3 (virgaureasaponin 3) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Reznicek G Jurenitsch J Plasun M Korhammer S Haslinger E Hiller K Kubelka W Four major saponins from Solidago canadensis. In: Phytochemistry (1991) 30(5):1629-33 ISSN: 0031-9422 Four new bisdesmosidic saponins each containing eight carbohydrate units were isolated from Solidago canadensis. GC, GC-MS, FABMS analysis and mainly the use of 2D NMR techniques allowed their identification as bayogeninglycosides (canadensissaponins 1-4) 3-O- [beta-D-glucopyranosyl-(1----3)-beta-D-glucopyranosyl]-28-O-[alpha-L- rhamnopyranosyl-(1----3)-beta-D-xylopyranosyl-(1----4)-[beta-D- xylopyranosyl-(1----3)]-alpha-L-rhamnopyranosyl-(1----2)-[beta-D- apio-D-furanosyl-(1----3)]-beta-D-6-deoxyglucopyranosyl- (1----]- bayogenin; -(1----2)-[beta-D-apio-D-furanosyl-(1----3)]-ara- binopyranosyl-(1----]-bayogenin; -[alpha-L-rhamnopyranosyl-(1----3)]- beta- D-6-deoxyglucopyranosyl-(1----]-bayogenin and -[alpha-L- rhamnopyranosyl- (1----3)]-arabinopyranosyl-(1----]-bayogenin. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PLANTA MEDICA***** Reznicek G Jurenitsch J Freiler M Korhammer S Haslinger E Hiller K Kubelka W [Isolation and structure elucidation of further new saponins from Solidago canadensis] Isolierung und Struktur weiterer neuer Saponine aus Solidago canadensis. In: Planta Med (1992 Feb) 58(1):94-8 ISSN: 0032-0943 (Published in German) Four new main saponins (canadensis-saponins 5-8) (compounds 5-8) were isolated from Solidago canadensis L. (Asteraceae). Using GC/MS, FAB- MS, and mainly 2D-NMR techniques their structures were identified as 3-O-[beta-D-glucopyranosyl(1----3)-beta-D- glucopyranosyl]-28-O-[beta- D-galactopyranosyl(1----2)-alpha-L- rhamnopyranosyl-(1----3)-beta-D- xylopyranosyl-(1----4)-[beta-D- xylopyranosyl-(1----3)]-alpha-L- rhamnopyranosyl-(1----2)-[beta-D-apio -D- furanosyl-(1----3)]-beta-D- 6-deoxyglucopyranosyl-(1----)]-bayogenin(5), 3-O- [beta-D- glucopyranosyl-(1----3)-beta-D-glucopyranosyl]-28-O-[beta-D- galactopyranosyl-(1----2)-alpha-L-rhamnopyranosyl-(1----3)-beta-D- xylopyranosyl-(1----4)-[beta-D-xylopyranosyl-(1----3)]-alpha-L- rhamnopyranosyl-(1----2)-[beta-D-apio-D-furanosyl-(1----3)]- arabinopyranosyl-(1----)] bayogenin(6), 3-O-[beta-D-glucopy ran osyl-(1- ---3)- beta-D-glucopyranosyl]-28-O-[beta-D-galactopyranosyl-(1----2)- alpha-L-rhamnopyranosyl-(1----3)-beta-D-xylopyranosyl-(1----4)-[beta- D- xylopyranosyl-(1----3)]-alpha-L-rhamnopyranosyl-(1----2)-[alpha-L- rhamnopyranosyl-(1----3)]-beta-D-6-deoxyglucopyranosyl-(1----)]-++ +bayogenin (7), and 3-O-[beta-D-glucopyranosyl-(1----3)-beta-D- glucopyranosyl]-28-[O- beta-D-galactopyranosyl-(1----2)-alpha-L- rhamnopyranosyl-(1----3)-beta-D - xylopyranosyl-(1----4)-[beta-D- xylopyranosyl-(1----3)]-alpha-L- rhamnopyranosyl-(1----2)-[alpha-L- rhamnopyranosyl-(1----3)]arabinopyr anosyl - (1----)[-bayogenin (8). €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Bader G Wray V Hiller K The main saponins from the aerial parts and the roots of Solidago virgaurea subsp. virgaurea. In: Planta Med (1995 Apr) 61(2):158-61 ISSN: 0032-0943 Two new (3, 4) and two known (1, 2) genuine acylated bisdesmosidic triterpenoid glycosides of polygalacic acid (2 beta, 3 beta, 16 alpha, 23-tetrahydroxyolean-12-en-28-oic acid) were isolated from the aerial parts, as well as from the roots, of Solidago virgaurea L. subsp. virgaurea. The structures of these esters were elucidated as 4- O-fucopyranosyl-acylated compounds (1, 2, 3, 4) of 28-[O-alpha-L- rhamnopyranosyl-(1-->3)-O-beta-D-xylopyranosyl- (1-->4)-O-alpha-L- rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl]-glycosides of 3-O- [beta-D-glucopyranosyl]-polygalacic acid (5), and 3-O-[O-beta-D- glucopyranosyl-(1-->3)-beta-D-glucopyranosyl]- polygalacic acid (6). €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€