€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****ACTA POLONIAE PHARMACEUTICA***** Klimek B 6'-0-apiosyl-verbascoside in the flowers of mullein (Verbascum species). In: Acta Pol Pharm (1996 Mar-Apr) 53(2):137-40 ISSN: 0001-6837 Phenylethanoid triglycoside acylated with caffeic acid was isolated from the inflorescences of V, lychnitis and identified as verbascoside 6'-0-beta-D-apiofuranoside (forsythoside B). It has also been found, that forsythoside B is one of the major constituents in the inflorescences of V. lychnitis and V. nigrum, whereas in the flowers of V. phlomoides and V. densiflorum it was hardly detectable. Registry Numbers: 331-39-5 (caffeic acid) 61276-17-3 (verbascoside) 67-56-1 (Alcohol, Methyl) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS***** Zgorniak-Nowosielska I Grzybek J Manolova N Serkedjieva J Zawilinska B Antiviral activity of Flos verbasci infusion against influenza and Herpes simplex viruses. In: Arch Immunol Ther Exp (Warsz) (1991) 39(1-2):103-8 ISSN: 0004-069X The lyophilized infusion from flowers of Verbascum thapsiforme Schrad. (FVI) showed antiviral activity in in vitro studies against Fowl plague virus, several influenza A strains, influenza B strain as well as Herpes simplex virus. Influenza viruses titer decreased by 1- 3 log units, while of H. simplex virus by 2.3 log. FVI has shown virucidal activity on H. simplex virus at 300 micrograms/ml, but did not inactivate influenza viruses. Phytochemical investigations of FVI have shown the presence of flavonoids, iridoids, phenolic acids, saponins, amino acids and free sugars. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF ETHNOPHARMACOLOGY***** McCutcheon AR Roberts TE Gibbons E Ellis SM Babiuk LA Hancock RE Towers GH Antiviral screening of British Columbian medicinal plants. In: J Ethnopharmacol (1995 Dec 1) 49(2):101-10 ISSN: 0378-8741 One hundred methanolic plant extracts were screened for antiviral activity against seven viruses. Twelve extracts were found to have antiviral activity at the non-cytotoxic concentrations tested. The extracts of Rosa nutkana and Amelanchier alnifolia, both members of the Rosaceae, were very active against an enteric coronavirus. A root extract of another member of the Rosaceae, Potentilla arguta, completely inhibited respiratory syncytial virus. A Sambucus racemosa branch tip extract was also very active against respiratory syncytial virus while the inner bark extract of Oplopanax horridus partially inhibited this virus. An extract of Ipomopsis aggregata demonstrated very good activity against parainfluenza virus type 3. A Lomatium dissectum root extract completely inhibited the cytopathic effects of rotavirus. In addition to these, extracts prepared from the following plants exhibited antiviral activity against herpesvirus type 1: Cardamine angulata, Conocephalum conicum, Lysichiton americanum, Polypodium glycyrrhiza and Verbascum thapsus. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PHYTOCHEMISTRY***** Hartleb I Seifert K Triterpenoid saponins from Verbascum songaricum. In: Phytochemistry (1995 Jan) 38(1):221-4 ISSN: 0031-9422 From the aerial parts of Verbascum songaricum the two new triterpenoid saponins songarosaponin E, F and the known buddlejasaponin I have been isolated and identified as 3-O-([beta-D- glucopyranosyl-(1-->4)-beta-D- glucopyranosyl-(1-->3)]-[beta-D- glucopyranosyl-(1-->2)]-beta-D- fucopyranosyl)-olea-11,13-diene-3 beta, 23,28-triol, 3-O-([beta-D- glucopyranosyl-(1-->4)-beta-D- glucopyranosyl-(1-->3)]-[beta-D- glucopyranosyl- (1-->2)]-beta-D- fucopyranosyl)-olea-11,13-diene-3 beta, 16 beta, 23,28-tetrol and 3-O- ([alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)]- [beta-D-glucopyranosyl-(1-->2)]-beta-D-fucopyranosyl)-13 beta, 28- epoxyolea- 11-ene-3 beta, 16 beta, 23-triol. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Hartleb I Seifert K Songarosaponin D--a triterpenoid saponin from Verbascum songaricum. In: Phytochemistry (1994 Mar) 35(4):1009-11 ISSN: 0031-9422 Songarosaponin D has been isolated from the aerial parts of Verbascum songaricum. Based on spectral evidence, the structure of songarosaponin D was elucidated as 3-O-([beta-D-glucopyranosyl-(1-- >4)-beta-D-glucopyranosyl-(1-->3)-]- [beta-D-glucopyranosyl-(1-->2)]- beta-D-fucopyranosyl)-13 beta,28-++ +epoxyolea-11-ene-3 beta,16 beta,23-triol. Registry Numbers: 155762-41-7 (songarosaponin D) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Warashina T Miyase T Ueno A Phenylethanoid and lignan glycosides from Verbascum thapsus. In: Phytochemistry (1992 Mar) 31(3):961-5 ISSN: 0031-9422 Verbascum thapsus afforded, in addition to three known phenylethanoid glycosides and four lignan ones, five new phenylethanoid glycosides and one new lignan glycoside. Structures of the compounds were elucidated by spectroscopic methods and chemical evidence. Registry Numbers: 60-12-8 (Phenylethyl Alcohol) 9005-53-2 (Lignin) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Klimek B Lavaud C Massiot G Saponins from Verbascum nigrum. In: Phytochemistry (1992 Dec) 31(12):4368-70 ISSN: 0031-9422 Two triterpene saponins have been isolated from the inflorescences of Verbascum nigrum. Their structures were determined by chemical and spectral methods as 3-O-([alpha-L-rhamnosyl-(1-->4)-(beta-D- glucopyranosyl-(1-->3)]-be ta-D-glucopyranosyl]-(1-->2)-beta- fucopyranosyl)-13 beta,28-epoxyolean-11-ene-3 beta,23-diol and 3-O- ([alpha-L-rhamnosyl-(1-->4)-(beta-D-glucopyranosyl-(1-->3)-bet a-D- glucopyranosyl]-(1-->2)-beta-fucopyranosyl)-11-methoxy-olean-12-en e- 3 beta,23,28-triol. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Seifert K Preiss A Johne S Schmidt J Lien NT Lavaud C Massiot G Triterpene saponins from Verbascum songaricum. In: Phytochemistry (1991) 30(10):3395-400 ISSN: 0031-9422 Songarosaponin A, B and C isolated from the aerial parts of Verbascum songaricum were shown to be 3-O-[alpha-L-rhamnopyranosyl-(1----4)- beta-D-glucopyranosyl-(1----3)]-[b eta-D-glucopyranosyl-(1----2)-beta- D-fucopyranosyl]-olea-11,13-die ne-3 beta-23,28-triol, 3-0-[alpha-L- rhamnopyranosyl-(1----4)-beta-D-glucopyranosyl-(1----3)]-[b eta-D- glucopyranosyl-(1----2)]-beta-D-fucopyranosyl]-olea-1 1-ene-3 beta- 13,23,28-tetrol and 3-O-[beta-D-glucopyranosyl-(1----4)]-[beta-D- glucopyranosyl-(1----3)]-[b eta-D-glucopyranosyl-(1----2)]-beta-D- fucopyranosyl]-13 beta,28-epoxyolea-11-ene-3 beta,23-diol. Registry Numbers: 141544-47-0 (songarosaponin B) 141544-48-1 (songarosaponin C) 141565-05-1 (songarosaponin A) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Klimek B Hydroxycinnamoyl ester glycosides and saponins from flowers of Verbascum phlomoides. In: Phytochemistry (1996 Dec) 43(6):1281-4 ISSN: 0031-9422 A new iridoid ester glycoside acylated with p-coumaric acid was isolated from the flowers of Verbascum phlomoides, together with one known one, specioside. Caffeic acid esters, verbascoside and forsythoside B were found as minor constituents. A new saponin was also obtained and identified as desrhamnosylverbascosaponin. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY***** Slagowska A Zgorniak-Nowosielska I Grzybek J Inhibition of herpes simplex virus replication by Flos verbasci infusion. In: Pol J Pharmacol Pharm (1987 Jan-Feb) 39(1):55-61 ISSN: 0301-0244 The preliminary phytochemical investigations have revealed the presence of flavonoids, iridoids, phenolic acids, saponins, amino acids, free sugars, and mucilages in the lyophilized infusion obtained from flowers of Verbascum thapsiforme Schrad. (FVI). Antiviral activity of the FVI on Herpes simplex type 1 virus (HSV-1) was studied in vitro by the yield reduction test. Decrease in the virus titer amounted to about 2.5 log at the non-toxic concentrations of FVI. The inhibitory effect of FVI on HSV studied by plaque reduction test in Vero cells showed that 50% inhibition of virus plaques occurred at 190 micrograms/ml. The virucidal effect of FVI on HSV was also shown. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€