€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****ACTA PHYSIOLOGICA ET PHARMACOLOGICA BULGARICA***** Voynova E Dimitrova S Naydenova E Karadjov P Inhibitory action of extracts of Maclura aurantiaca and Epilobium hirsutum on tumour models in mice. In: Acta Physiol Pharmacol Bulg (1991) 17(4):50-2 ISSN: 0323-9950 Primary screening of alcohol extracts of fruits of Maclura aurantiaca (Moraceae) and the overground part of Epilobium hirsutum (Onagraceae) was conducted in order to test the anti-tumour action on models in mice. Applied in doses of 100 mg/kg and 90 mg/kg, Maclura extract increased the life span of the mice by 158 and 152% accordingly in leucosis P-388 and ascitic tumour of Ehrich. In doses of 1 mg/kg and 3 mg/kg the Epilobium extract prolonged the life span of the mice by 156 and 158% accordingly in leucosis P-388 and ascitic tumour of Ehrlich. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****BASIC LIFE SCIENCES***** Ivancheva S Manolova N Serkedjieva J Dimov V Ivanovska N Polyphenols from Bulgarian medicinal plants with anti-infectious activity. In: Basic Life Sci (1992) 59:717-28 ISSN: 0090-5542 Three Bulgarian medicinal plants--Geranium macrorrhizum L. and G. sanguineum L. (Geraniaceae), and Epilobium hirsutum L. (Onagraceae) were analyzed phytochemically. Different polyphenols like flavonoids and tannis have been found to be principal constituents of the plants. A series of water or alcohol extracts was obtained, and their anti-infectious activity was tested. A significant inhibitory effect of water-alcohol extract and of four fractions from the polyphenolic mixture of E. hirsutum on the reproduction of influenza viruses in vitro, in ovo, and in vivo was established. Four extracts from G. macrorrhizum and three extracts from G. sanguineum were studied for in vitro inhibition of the growth of some Gram-negative bacteria (Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacterium (Staphylococcus aureus), and fungus (Candida albicans). Some geranium extracts caused a strong increase of the survival rate in an infection with K. pneumoniae in mice. Augmentation of the nonspecific host resistance in relation to the influence of the extracts on the classical complement activation pathway was also studied. €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****JOURNAL OF NATURAL PRODUCTS***** Lesuisse D Berjonneau J Ciot C Devaux P Doucet B Gourvest JF Khemis B Lang C Legrand R Lowinski M Maquin P Parent A Schoot B Teutsch G Determination of oenothein B as the active 5-alpha-reductase- inhibiting principle of the folk medicine Epilobium parviflorum. In: J Nat Prod (1996 May) 59(5):490-2 ISSN: 0163-3864 Several extracts from Epilobium parviflorum, a plant used in Central Europe for the treatment of prostate disorders, were evaluated in a biochemical assay with 5-alpha-reductase. The aqueous extract displaying inhibition of the enzyme was analyzed, the fraction responsible for this activity was purified, and the active compound identified as a macrocyclic tannin, oenothein B (1). Registry Numbers: EC 1.3.99.5 (Testosterone 5-alpha-Reductase) 104987-36-2 (oenothein B) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ *****PLANTA MEDICA***** Hiermann A Reidlinger M Juan H Sametz W [Isolation of the antiphlogistic principle from Epilobium angustifolium] Isolierung des antiphlogistischen Wirkprinzips von Epilobium angustifolium. In: Planta Med (1991 Aug) 57(4):357-60 ISSN: 0032-0943 (Published in German) From the leaves of Epilobium angustifolium L. (Onagraceae) an antiphlogistic principle was isolated and identified as myricetin 3-O- beta-D-glucuronide. This novel flavonoid exhibited a very strong anti- inflammatory effect on carrageenan-induced edema in the rat hind paw (more than ten times more effective than indomethacin) and an inhibitory effect on prostaglandin biosynthesis (as effective as indomethacin). Registry Numbers: 77363-65-6 (myricetin 3-O-glucuronide) €€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€