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*****ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS*****
Zielinska-Jenczylik J  Sypula A  Budko E  Rzadkowska-Bodalska H  
Interferonogenic and antiviral effect of extracts from Erodium cicutarium. II.
Modulatory activity of Erodium cicutarium extracts.
In: Arch Immunol Ther Exp (Warsz) (1988) 36(5):527-36
ISSN: 0004-069X

Methanol extract from Erodium cicutarium was shown not to induce interferon in a
suspension of human leukocytes or in the cutaneo- muscular tissue of human
embryo. It appeared to have no influence, either direct or cell-mediated, on
interferon activity. However, it exerted stimulatory effect on the synthesis of
interferon induced with Newcastle disease virus in cell cultures. The
stimulation occurred irrespective of the time of methanol extract administration
(before or after viral inducer). In the in vivo experiments, methanol extract
injected intravenously induced interferon in mice. When given 24 h prior to
Newcastle virus, it increased the titer of induced interferon determined in the
animal serum collected 6 h after the virus injection. Besides, in the
experimental viral infection in mice replication of influenza A virus in the
lung tissue of infected animals was inhibited only when the mice were treated
with methanol extract 24 and 48 h after infection with the virus.

Registry Numbers:
9008-11-1 (Interferons)

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*****YAO HSUEH HSUEH PAO [ACTA PHARMACEUTICA SINICA]*****
Zhang YY  Li SH  Tian Z  
[Morphological and histological studies of the Chinese drug lao-guan- cao]
In: Yao Hsueh Hsueh Pao (1995) 30(1):46-58
ISSN: 0513-4870  (Published in Chinese)

Lao-guan-cao has long been used in Chinese traditional medicine. It is used as
an antirheumatic and circulation promoting drug for the treatment of acute and
chronic rheumatalgia; also used as a detoxicant for enteritis and bacillary
dysentery. The dried aerial parts of Erodium stephanianum Willd. and Geranium
wilfordii Maxim. (family Geraniaceae) have been specified in the Chinese
Pharmacopoeia (1990 ed.) According to the literature and the authors' market
investigations, the commercial drug Lao-guan-cao chiefly consists of the aerial
parts of Erodium stephanianum Willd. Also those rather popularly used in several
provinces are the aerial parts of Geranium nepalense Sweet and G. sibiricum L.
In this paper, the morphological and histological characters of the crude drugs
derived from E. stephanianum Willd., G.nepalense Sweet and G.sibiricum L. are
described. It is found that the following characters are useful for
distinguishing the drugs derived from the above mentioned three species. (1) The
shape and size of leaf; (2) the number and arrangement of the vascular bundles
of stem; (3) the number of the vascular bundles in midrib and layers of palisade
cells of leaf; (4) the presence or absence of stomata in upper epidermis; (5)
the characters of cells containing crystals in sepal; (6) the characters of
epidermis cells, cells containing crystals and fibers of pericarp; (7) the types
of hairs and glandular hairs on epidermis of stem, leaf, sepal and pericarp; (8)
the characters of anticlinal walls of epidermal cells of seed coat.

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*****ZEITSCHRIFT FUR NATURFORSCHUNG. SECTION C. JOURNAL OF BIOSCIENCES*****
Sroka Z  Rzadkowska-Bodalska H  Mazol I  
Antioxidative effect of extracts from Erodium cicutarium L.
In: Z Naturforsch [C] (1994 Nov-Dec) 49(11-12):881-4
ISSN: 0341-0382

Extracts from Erodium cicutarium L. (EC) and some standard substances present in
EC extracts were tested for their antioxidative properties during Fe(2+)-induced
triglyceride oxidation. Hydrophobic fractions such as petroleum ether (PEE),
benzene (BE) and chloroform I (ChE I) extracts as well as hydrophilic fractions
i.e. water (WE) and ethyl acetate (EAE) showed an antioxidative effect. Among
the tested substances vitamin C and some polyphenolic compounds: tannin, (+)-
catechin and gallic acid exhibited antioxidative activity, stronger than the one
of the mentioned extracts.

Registry Numbers:
50-81-7 (Ascorbic Acid)]
7439-89-6 (Iron)

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